Transform EGF Serum™
A powerful boost of liposome-encapsulated Epidermal Growth Factor (EGF) peptides to support Dermal-Epidermal Junction (DEJ). EGF is a strong promoter of fibroblast proliferation which supports collagen production.
Essential fatty acids from coconut recondition skin and improve barrier strength, while essential oils provide pore minimizing, age-defying properties. Great for all skin types.
- Enhances Lipid Barrier Function
- Strengthens Thin, Aging Skin
- Collagen Supporting
Sh-Oligopeptide-1 – (Epidermal Growth Factor aka EGF) 1% (efficacy studies at 1%): A peptide that has shown to fast-track the development of anti-aging properties by addressing natural skin exfoliation, turn-over and proliferation which in turn helps to soften the appearance of fine lines and wrinkles, while also working synergistically to boost healthy complexion results. EGF is capable of thickening tissue layers while enhancing barrier function. Please see more info below.
ChroNOline™ (Caprooyl Tetrapeptide-3) 3% (efficacy studies at 0.3 – 2.5%): A peptide derived from a growth factor, helps to support Dermal-Epidermal Junction (DEJ) components, aids in boosting natural collagen benefits and renewal, helps to soften the appearance of fine lines. Skin benefits include wrinkle reduction, skin rejuvenation, evenness of skin texture, and firmer/smoother skin.
Cococin™ [Cocos Nucifera (Coconut) Fruit Juice]: Rich in Essential Fatty Acids (EFA), assists in reconditioning the skin and improving lipid barrier strength, moisturizing and helps to promote a healthier complexion.
What is EGF and How It Works
Epidermal Growth Factor (EGF) and Skin Regeneration
Healing and regeneration are two important concerns for providing optimum skin care. Aging is viewed as a process of small-scale injury that accumulates over time. Addressing this damage isn’t just a trend, but more of a consumer desire that has spanned the ages. Evidence of this includes the ancient Egyptians use of dairy products on their skin to leave it looking smooth and feeling supple. A more modern-day interpretation of this desire is the use of Live Yeast Cell Derivative (LYCD). Fashion models began this ingredient trend in cosmetics during the 1970s, when they started using Preparation-H to soothe their tired looking eyes. Current techniques that are being employed to address the desire for healing and regeneration include bio-technologically derived actives such as Epidermal Growth Factor (EGF).
EGF is a strong promoter of epithelial and fibroblast proliferation. It is widely recognized for its ability to enhance wound repair by promoting collagen production. As we age, our dermis and epidermis thin and barrier function becomes compromised. This results in wrinkle formation and dry skin. Unfortunately, the loss in hydration compounds the problem by making wrinkles more apparent. Research indicates that EGF is capable of thickening tissue layers while enhancing barrier function. This will minimize the appearance of wrinkles and improve hydration. A study commissioned by the Department of Surgery at Emory University in Atlanta; Georgia illustrated the wound reparative properties of EGF on 12 subjects. Researchers reported a significant increase in the rate of wound repair on all 12 subjects when compared to the placebo. After one day subjects had a 25 to 50% rate of improved healing. By day two, researchers reported a 75 to 100% rate of recovery on areas treated with EGF. Other research indicates that EGF is capable of enhancing DNA replication to further promote regeneration thus ensuring wound repair. A study performed on human excised skin tissue has revealed that upon injury, EGF is released in the skin and activates EGFR (epidermal growth factor receptor). Inhibition of EGF in this study was shown to retard reepithelization.
1) Brown, GL. et. al. Enhancement of wound healing by topical treatments with epidermal growth factor. The New England Journal of Medicine. Volume 321:76- 79. July 13, 1989. [Retrieved: July 7, 2009].
2) Nanney, Lillian. Epidermal and dermal effects of epithelial growth factor during wound repair. Journal of Investigative Dermatology (1990) 94, 624-629.
[Retrieved: July 7, 2009].
3) Jo, Byoung Kee. Cosmetic composition for skin care containing retinol and epidermal growth factor. Unites States Patent 6,589,540. [Retrieved: July 9, 2009].
[Retrieved: July 9, 2009].
4) Sorensen, Ole. et. al. Injury-induced innate immune response in human skin mediated by transactivation of the epidermal growth factor receptor. J. Clin. Invest. 116(7): 1878- 1885 (2006). [Retrieved: July 9, 2009.]
5) Oda, Kanae. et. al. A comprehensive pathway map of epidermal growth factor receptor signaling. Mol Syst Biol. 2005; 1: 2005.0010.
Apply to skin in AM and PM, follow with your favorite Botanical Rush nourishing cream.
INCI Ingredients: (*organic) Hamamelis virginiana (witch hazel) water, aqua (water), alcohol, glycerin, polysorbate 20, sh-Oligopeptide-1 (EGF), caprooyl tetrapeptide-3, cocos nucifera (coconut) fruit jice, lavandula angustifolia (lavender) oil, citrus paradisi (pink grapefruit) peel oil*, citrus aurantium dulcis (orange) peel oil*, santalum austrocaledonicum (sandalwood) wood oil, boswellia carterii (frankincense) oil, rosa damascena flower oil, phospholipids, dextran, xanthan gum, gluconolactone, sodium benzoate